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• my70size.com:

  26/10/2025 в 23:06

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• bantoomusic.com:

  30/10/2025 в 05:34

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• Cool-Down After Triceps Workout:

  01/11/2025 в 01:40

  They regularly have robust opinions about laboratory results and
  treatment strategies, based on biased and incomplete information. We noted a high proportion of former AAS abusers exhibiting signs
  suggestive of useful hypogonadism. We didn’t observe any associations between these signs and reproductive hormone levels.
  Previous studies have proven supraphysiologic doses of testosterone (≥ 500 mg/week)
  sometimes induce hypomania or mania in healthy younger males and that fast decreases in testosterone levels could cause depressive signs and decreased libido [32, 33].
  The signs we observed among former AAS abusers could have been a consequence of
  abrupt decreases in plasma androgens, from supraphysiologic ranges to
  low or normal ranges, following AAS withdrawal,
  versus particular plasma testosterone levels.

  Kanayama et al. launched the time period «muscle dysmorphia»
  and noted it as being extremely prevalent amongst AAS abusers and a cause
  of dependence [34]. Declines in muscle mass resulting in a extra regular physique composition, might have brought on body image concerns among
  former AAS abusers in this research in addition to practical signs of hypogonadism, Cool-Down After Triceps Workout AAS cessation.
  Mesterolone is also available for the treatment of male hypogonadism but it is seldom used, if in any
  respect. Anabolic steroids also stimulate erythrocyte synthesis, which could be helpful in the therapy of hypoplastic anaemias however their use in wealthy countries is likely to
  be restricted with the relative recent availability of recombinant human erythropoietin and its
  analogues. In postmenopausal women, the treatment of osteoporosis with anabolic steroids, such as nandrolone decanoate, isn’t advocated given the success of oestrogen substitute and, more just lately, with
  the introduction of the biphosphonates. In contrast with the opposed
  effect on LDL- and HDL-cholesterol, AAS appear to exert
  a neutral or favorable impact on lipoprotein (a) (Lp(a)).

  Elevated Lp(a) ranges are considered an established causal danger issue for CVD (140).
  In a double-blind trial, nandrolone decanoate (200 mg weekly) for eight
  weeks decreased Lp(a) in contrast with baseline, however not compared with placebo, in a gaggle of bodybuilders (124).
  In the same publication, a second nonblinded trial is described during which AAS customers
  self-administer their very own cycle.
  Tensions between some AAS users and the medical community are well documented [26, 67–69] and lengthy established [70], predating anti-doping or legislative management in most nations.
  Although psychological harm and the potential demand for interventions to deal with dependence are also
  properly recognised [71–75] and diagnostic
  instruments out there [52, 76], obtainable companies are few and far between. This research additionally identified a significantly lower FMD response in AAS customers in comparability with the WLC group.

  Moreover, AAS are sometimes taken in cycles, with deliberate off-drug
  durations, to decrease potential liver toxicity and
  opposed effects. This professional evaluation will discover the relationship between AAS use and CV risk and supply an approach to the management of AAS within the
  sports activities cardiology clinic. Anabolic-androgenic steroids (AASs),
  commonly known as anabolic steroids, are a large
  group of molecules including endogenously produced androgens, corresponding to testosterone, as properly as synthetically manufactured derivatives [1].
  Testosterone, Nandrolone Decanoate (ND), methandienone, and methenolol, are probably the most commonly abused androgens [2].
  AAS use is widespread as a result of their capability to enhance muscle progress for
  esthetic purposes and athletes’ performance,
  minimizing androgenic results [3]. Certainly, androgens are able to enhance the size of muscle fibers as nicely as muscle energy,
  and whereas their use was initially restricted to skilled bodybuilders, these days it has
  turn into more in style amongst leisure athletes [4,5].
  Certainly, AASs had a role within the remedy of chronic kidney illness and osteoporosis in postmenopausal women,
  as well as inoperable breast most cancers, and for ailments characterized
  by a adverse nitrogen stability [2].
  The time period has been criticized and deemed obsolete since all compounds included on this
  group bind and activate the androgen receptor, making them
  basically androgens, which, by definition, have muscle constructing and virilising effects (4).

  Injectable testosterone esters are among the many AAS
  most used, however there’s a broad variety of artificial derivatives available.
  Testosterone, as most different AAS, undergoes intensive metabolism when administered orally.

  Subsequently, some AAS have been alkylated to increase bioavailability after oral
  administration. However, decades ago, it became evident that 17-alkylated androgens are hepatotoxic and clinical utility was largely deserted (5).
  Though most AAS abusers are nicely aware of this, oral AAS,
  corresponding to methandienone (Dianabol), chlorodehydromethyltestosterone (Turinabol),
  oxandrolone (Anavar) and stanazolol (Winstrol), are nonetheless broadly abused.
  With Out modification, steroids quickly enter the blood, leading to
  excessive peak ranges and a very quick plasma half-life.

  Intercourse steroid-induced suppression of spermatogenesis reduces testicular quantity by
  sixteen.5–30.0% (176, 182, 183). Some AAS customers
  would possibly, due to this fact, resort to the utilization of hCG or human menopausal gonadotropin (hMG) to take care of testis volume rather
  than looking for to protect fertility per se. AAS users
  are more probably to have giant upper arm circumferences, and an inappropriately small cuff will overestimate blood stress.
  The importance of utilizing an appropriate cuff measurement in a muscular inhabitants was underscored in a trial inspecting blood strain in a
  cohort of aggressive bodybuilders (96). In those
  with an upper arm circumference larger than 33 cm, systolic blood stress was 8.2 mmHg larger using cuff
  dimension M in contrast with cuff dimension L.
  As a end result, 33% of the themes can be classified as hypertensive
  utilizing the – inappropriate – cuff dimension M,
  whereas solely 12% can be classified as such using cuff size L.

  However, AAS use is still extremely popular and 1–3%
  of US inhabitants have been estimated to be AAS users [6]. Nevertheless, AASs have unwanted aspect effects involving all organs, tissues and body features, especially long-term
  toxicity involving the cardiovascular system and the reproductive system, due to this fact, their
  abuse is taken into account a public health concern [9,10].
  In this regard, an increased awareness is required among
  the inhabitants and healthcare staff, each for diagnostic, therapeutic and
  prevention functions. The purpose of the proposed review is to spotlight the state-of-the-art concerning the mechanisms of action of AASs and the
  adverse results associated to AAS use/abuse.
  AAS, anabolic androgenic steroids, AMH, anti-Müllerian hormone; DHEAS,
  dehydroepiandrosteronsulfate; FSH, follicle-stimulating hormone; LH, luteinizing hormone; P-, plasma; S-,
  serum SHBG, sexual hormone-binding globulin. Former AAS abusers
  exhibited significantly decrease plasma testosterone ranges and higher frequencies
  of signs suggestive of hypogonadism than healthy control members
  years after AAS cessation. Present AAS abusers exhibited
  severely decreased AMH and inhibin B indicative of impaired
  spermatogenesis. Contraindications for the use of antiandrogens are
  allergy to the drug or its parts and liver dysfunction or elevated liver enzymes.
  The antagonistic results of antiandrogens embody gynecomastia, breast ache, sizzling flashes,
  decreased libido, impotence, diarrhea, anemia,
  and abnormal liver perform. Antiandrogens are medications that compete with
  testosterone for androgen-receptor binding sites; in other words,
  they work towards androgens and testosterone.
  Antiandrogens either stop these hormones from binding to proteins in the
  target cells or lower the amount of a hormone produced.

  Testosterone is used as a baseline commonplace that every one different
  anabolic steroids are measured towards. These values clarify
  a lot concerning the steroid, they usually assist
  to determine what the compound is able to. Taking high doses of corticosteroids for
  a really long time could cause severe side effects like brittle bones that break simply (osteoporosis), sluggish
  progress in children, and a life-threatening situation referred
  to as adrenal insufficiency, where the physique can not respond
  to stress corresponding to surgical procedure
  or sicknesses. Other unwanted effects are muscle weak spot, eye issues (including cataracts), and
  a higher risk of diabetes. Steroids are comparatively small
  molecules, for example, testosterone has a molecular weight of 288,
  and they can passively diffuse into cells. In target tissues, that is, the
  cells that contain steroid receptors, the hormone binds to the receptor ligand-binding domain, inflicting dissociation of the receptor–Hsp90 advanced, the resultant conformational (allosteric) change making the receptor
  lively.

• Conseils nutritionnels minceur:

  01/11/2025 в 04:25

  The primary medical use of beta-blockers is
  to control hypertension, cardiac arrhythmias, angina
  pectoris (severe chest pain), migraine, and nervous or anxiety-related conditions.
  Socially, users could withdraw from family and friends, neglect obligations, and turn into secretive about their steroid use.

  Monetary difficulties and authorized issues may come up from the cost of
  obtaining steroids, particularly if they are acquired illegally.
  Whereas these strategies are thought to maximise positive aspects and reduce side
  effects, they really enhance the probabilities of harmful health complications.
  This examine included animal research and articles that have been older than 10 years.

  Since the discovery and synthesis of testosterone in the
  Thirties, AAS have been utilized by physicians
  for many functions, with various degrees of success.
  Erectile dysfunction is outlined as the lack to achieve or maintain an erection sufficient for satisfactory sexual efficiency
  (189). Testosterone plays an necessary role in almost every side of erectile operate
  (190) and erectile dysfunction is considered a suggestive
  symptom of testosterone deficiency (191).
  The formulation additionally reveals giant
  intra- and interindividual variation in bioavailability, making it cumbersome for alternative remedy.

  To handle this, testosterone undecanoate has lately been formulated in a self-emulsifying
  drug delivery system (SEDDS) to further improve lymphatic absorption and scale back intra-
  and interindividual variation (10). Nevertheless, it must be dosed twice every day to maintain physiological testosterone ranges all through the day.
  An different strategy facilities round significantly retarding metabolism of the compound.

  This structural modification tremendously increases oral bioavailability,
  though it comes with hepatotoxicity (11).
  Steroids have a powerful anti-catabolic effect on muscle tissue (after all, they’re ANABOLIC steroids – the other of catabolic).
  Stress hormones like cortisol, naturally rising throughout
  intense train, contribute to muscle breakdown and loss. Anabolic steroids are totally different from common steroids, known as corticosteroids, that are
  anti-inflammatory drugs similar to prednisone and cortisone, based on the Cleveland
  Clinic. But some social media users might have forgotten these high-profile downfalls, as they boast
  of the health and muscle features from taking the same unlawful medicine.
  If dysphonia is detected early on, the consequences could
  be reversed through discontinuing using steroids.
  To combat these results, a quantity of athletes additionally
  use oestrogen-suppressing medication generally identified as aromatase inhibitors.

  The goal is to maintain the height level in the middle third of the conventional vary, keep away from the potential toxicity of supernormal testosterone ranges, and
  relieve the specific symptom of hypogonadism that justified its use initially.
  There is no have to verify trough levels if the affected person just isn’t symptomatic.
  If you inject anabolic steroids and share a needle with others, you’re at nice danger
  of getting HIV, hepatitis B, and hepatitis C. Overdose
  can result in extreme liver injury, which could be deadly.[16] Steroid use can also lead to impulsive and aggressive
  habits, which may put them at increased danger of accidental or violent
  dying. Here’s every little thing you need
  to find out about anabolic steroids and their effects.
  Using steroids over an prolonged period of time can lead to irreversible
  damage to the organs and feminine reproductive system.

  Bodybuilders underneath our care have used steroids corresponding to Proviron, Trenbolone,
  Anavar, and Winstrol to flush out as a lot fluid as possible.
  We have found that steroids lower collagen production, inflicting the
  pores and skin to turn out to be thinner. Consequently, there’s less dermis masking the veins, enabling them to be positioned nearer to the surface of the
  skin. Medical studies additionally correlate androgen deficiency
  with decreased cognitive perform. Anabolic steroids
  are unlawful to make use of for cosmetic purposes in most
  nations, together with the US and UK; nevertheless, several are FDA-approved on a
  prescription foundation. Assist groups and peer counseling can even play an important role in recovery.

  Regardless Of the debate in the scientific group
  as to the effectiveness of anabolic steroids as performance enhancers
  in men, male athletes and bodybuilders continued to make use of them, understanding from their very own experimentation that they
  have been efficient. Androgenic-anabolic steroids (AAS) are synthetic derivatives
  of the male hormone testosterone. They can exert strong effects on the
  human body that may be helpful for athletic efficiency.

  In addition to the bodily unwanted effects of anabolic steroid misuse,
  there are also some psychological effects to remember.
  These embrace temper swings, paranoia, aggressive behavior, hallucinations, and manic conduct.
  Aside from steroids, athletes typically use non-steroidal
  compounds that primarily embrace human development hormone and insulin-like
  development issue. Even although they are usually prescribed for medical reasons, they’re usually misused for efficiency enhancement.

  References:

  Conseils nutritionnels minceur