Gon Kontora Podcast for SCAPP 004: New Wave special

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• Hvilken form for Clenbuterol er bedst?:

  01/11/2025 в 02:50

  Testosterone is produced instantly from the ovaries and also through conversion of weaker androgens, androstenedione
  and dehydroepiandrosterone (DHEA), which are synthesized by
  the ovaries and the adrenal glands, respectively.
  In young premenopausal girls, the ovary is answerable for roughly
  25% of the testosterone manufacturing, whereas 75% is derived from the adrenal androgens.
  However, in postmenopausal women, the ovary turns into a significant supply of
  testosterone production and its contribution will increase to
  50% (Adashi, 1994). Though the climacteric ovary is atrophic and
  loses its capability to synthesize estradiol and follicles, it continues to secrete androgens beneath the stimulation of postmenopausal gonadotropins (Sluijmer et al., 1995; Dowsett et al., 1980; Dennefors et al., 1980).
  AAS habit is generally thought-about to be a psychic habit, but the withdrawal results that occur when AAS use stops clearly point out an element of physical addiction as properly.

  If the testosterone could be very excessive but the FSH and LH ranges are low, this offers proof that the particular person is using anabolic steroids.
  AAS-induced hepatotoxicity was hypothesized to be related to oxidative stress
  in hepatic cells. Following AR receptor activation a rise in reactive oxygen species
  may be noticed due to the increase in mitochondrial
  b-oxidation. Moreover, antioxidant substances have a protective function against hepatotoxicity mediated by AASs.
  It was also demonstrated that androgenic potency and metabolic resistance are positively
  linked to the diploma of liver harm [82].
  Other short-acting testosterone preparations embody those which are designed to
  be administered by the sublingual or buccal route.
  Such short-acting formulations are of specific concern in sport, because the exogenous source of
  testosterone is rapidly eradicated following cessation of treatment.
  Elevated out-of-competition testing helps to combat the
  cheat who is utilizing short-acting preparations and ceasing administration previous to competition in anticipation of testing.
  It is of curiosity that a bootleg preparation known as ‘The
  Cream’ was designed for transdermal utility (see the part ‘Designer steroids’).
  This is a creating subject and the comparative importance of many of these coregulators is
  but to be established for any explicit cell kind, let alone their relative in vivo importance in analyzing tissue differences
  in androgen action. It is envisaged that genetic
  manipulation of the mouse will help in elucidating their physiological relevance.
  Testosterone is irreversibly converted by the enzyme 5α-reductase to 5α-dihydrotestosterone (DHT), which binds with greater affinity to
  the androgen receptor (AR), or by aromatase to oestradiol, which
  binds to the oestrogen receptor (ER).
  Their deleterious effect is further augmented by the fact, that such tumors
  have a excessive incidence in young individuals, the
  cohort of people abusing AAS. Additional research are needed to analyze
  the potential link between AAS abuse and cancer. AASs are
  a identified cause various useful problems, which may have an result on liver, cardiovascular, reproductive, musculoskeletal,
  endocrine, renal, immunologic or neuropsychiatric systems.

  Past these deleterious macro-effects, testosterone-derived androgens could act directly on cellular capabilities, with either genetic or epigenetic elements figuring out toxic,
  mutagen, genotoxic and carcinogenic results.
  AAS can even affect cancer cell proliferation via genomic and non-genomic mechanisms, such because the so-called estrogen-dependence mediated by ER,
  aromatase expression and IGF-1 production, which may even amplify each other.
  Due To This Fact, IGF-1 can be thought-about as a
  well-known most cancers inducer and promoter affecting each stage of tumor development, from cellular proliferation to the
  metastatic phase.
  Anyone who needs to make use of them, whether for medical causes or to enhance
  their efficiency in sports, must know these variations.
  Starting with testosterone as the one anabolic steroid in your first
  cycle lets you start with probably the most essential steroid of all, which will check your body’s tolerance and
  response to steroids very quickly. After all, if
  you experience adverse effects in a fundamental testosterone-only cycle, then there’s
  a larger probability of antagonistic reactions to the numerous different steroids out there, many of which are derivatives of testosterone.
  If testosterone is not included in every cycle, signs of low or no testosterone will occur not solely whereas you’re using steroids but in addition after your cycle ends, in addition to it takes some time for natural
  production to start growing again. Post-cycle remedy is also a
  crucial area that will contribute to getting your pure
  testosterone levels back on track after a steroid cycle.
  Facet results to expect with this steroid embody testosterone suppression, mild unfavorable impact
  on ldl cholesterol, and comparatively low danger of
  androgenic effects in men like hair loss and pimples.
  Equipoise has a low degree of estrogenic activity, so these
  unwanted effects should be easy to control.

  For this purpose, they’re reserved only for reasonable to extreme
  inflammatory circumstances (34). A common psychological side impact of AAS use
  is muscle dysmorphia, by which customers become preoccupied with having
  a muscular physique (31). The solely method to acquire and
  use AAS legally would be to have them prescribed by
  a medical skilled for a sure situation, similar to low testosterone or a muscle-wasting disease.

  When it involves bodybuilding, Oxandrolone is popular as a outcome of it’s extremely anabolic and minimally androgenic.
  Due To This Fact, it’s typically chosen by those that do not need to use a number
  of the more potent steroids on the market, together with
  women. Anavar does not require injections and is taken orally as a tablet, which is one
  other attractive profit for those new to utilizing steroids.

  Doctors use these medication to assist deal with delayed puberty, and enhance muscle mass and power in individuals who have circumstances that cut back muscle tissue.
  Some docs prescribe it Hvilken form for Clenbuterol er bedst? testosterone supplementation remedy to improve temper and sexual performance in older males.
  AAS administration leads to a adverse suggestions on the
  hypothalamic-pituitary axis, altering the secretion of both FSH and LH,
  inflicting infertility [5]. A latest study focused on Leydig cell cultures treated
  with ND, demonstrating an impairment of testosterone manufacturing due to STARR and CYP17A1 expression interference
  in these cells [100].

• PedsElite:

  01/11/2025 в 06:09

  Try to scale back caffeine consumption in levels, beginning by decreasing the dose to as soon as a day, preferably solely taking
  caffeinated drinks within the morning, then you can begin to ask for half-caffeinated and eventually swap
  fully to decaffeinated. Testosterone is an aggressive hormone and as
  with males, when women take testosterone they turn into more aggressive and prone to robust emotions corresponding to exaggerated anger that can lead to violence.
  Some girls might develop neurological complications similar
  to hand and physique shaking as seen in folks with Parkinson’s disease.

  •The sufferers had the option to either proceed the remark or start receiving
  therapy medications if they might not tolerate AAS withdrawal symptoms.
  The sufferers have been randomized to untreated and handled
  teams based on their selection. In severe instances,
  males can expertise a whole failure in sperm manufacturing
  resulting in azoospermia (no sperm in the ejaculate).

  Whereas not all steroid users will become completely infertile, the potential for everlasting infertility
  exists. Components influencing this end result include the
  period of steroid use, dosage, and particular person susceptibility.
  The potential long-term consequences of hormonal disruption embody
  permanent harm to the testes and endocrine system, making it challenging to regain natural hormone production and fertility.
  For those fighting infertility after steroid use,
  fertility therapies similar to assisted reproductive technologies
  (ART) could also be essential.
  Without ovulation, there is no egg available for fertilization, resulting in infertility.
  In conclusion, while Anavar can enhance athletic
  performance, its impression on female hormones
  and subsequent fertility shouldn’t be overlooked.
  As we explore further into whether «Anavar can have an result on fertility in females,» it becomes crucial to contemplate what you truly need out of
  your health journey and the means it aligns with your long-term well being targets.
  For instance, a research performed by the College of California San Francisco found that Anavar use can lead to a
  decrease in sperm count and motility, in addition to
  a rise in abnormal sperm morphology. Regular testosterone
  manufacturing in the body is dependent upon the hypothalamic-Pituitary-Gonadal (HPG) axis.
  The testes make testosterone and when their manufacturing drops, the hypothalamus triggers the pituitary gland to launch a chemical
  called Luteinizing hormone (LH). Taking exogenous (from exterior the body) testosterone disrupts this axis
  and suppresses LH release.
  We included men aged years old, who acquired therapy within the men’s well being clinic on the College of Miami and patients placed
  on clomiphene citrate and/or hCG following the initial evaluation. Each
  sufferers taking prescribed steroids by way of a provider and those using
  steroids recreationally were included. Impression These with a
  historical past of pelvic radiation, chemotherapy, or
  radical orchiectomy were excluded. We conducted a retrospective review of adult males
  identified with infertility as a result of persistent AAS use
  between 2012 and 2022 at the University of Miami.
  The research included men with azoospermia or severe oligospermia who have
  been instructed to stop utilizing AAS. We collected data
  on demographic characteristics, AAS route particulars, fertility therapies, and AAS resumption.
  Whereas the addition of a progestin results in nearly undetectable gonadotropin levels, and consequently to azoospermia or severe oligozoospermia in the vast majority of men, a
  small proportion of men remain doubtlessly fertile (183, 184).
  One cause for this could be that the low intratesticular testosterone
  levels derived from the circulation continue to
  stimulate spermatogenesis in some males (180).

  In the HAARLEM examine, almost all subjects had undetectable LH and FSH ranges
  during AAS use.
  The significance of utilizing an applicable cuff measurement in a muscular population was underscored in a trial examining blood strain in a
  cohort of competitive bodybuilders (96). In these with an upper arm circumference larger
  than 33 cm, systolic blood strain was eight.2 mmHg greater using cuff dimension M compared with cuff dimension L.
  As a outcome, 33% of the subjects can be categorised as hypertensive
  using the – inappropriate – cuff measurement M, whereas only 12% can be categorized as such utilizing cuff size L.
  It ought to be famous that cuff dimension was adjusted in accordance with upper arm circumference within the HAARLEM research, and thus the outcomes were not affected by this problem (46).
  Ever because the preliminary isolation of testosterone by Ernst Laqueur’s group in the Netherlands in 1935 (79), and
  its synthesis by the Germans Adolf Butenandt and Günter Hanisch that same year (80), the prostate gland has acquired special attention in androgen analysis.
  In particular, an affiliation between testosterone therapy and prostate cancer was rapidly drawn based on animal experiments and limited case
  studies (81).
  Current evidence suggests, however, that adjuvant drugs could
  be prescribed in an effort to maintain testicular health
  and fertility while receiving TTh. A sustained increase in testosterone ranges during ‘cycles’ leads to greater aromatization charges of testosterone,
  which accounts for the gynecomastia typically
  present in steroid users. They include the uncommon hepatic peliosis, cholestatic jaundice and hepatic neoplasms, such as focal
  nodular hyperplasia, which are all closely related to dose and period of usage
  [20]. The goal of ‘stacking’ is to rationally
  mix different traits, avoiding overlap of benefits or unwanted effects.

  ‘Mass-building stacks’ encompass the combination of testosterone and nandrolone (or comparable drugs),
  used to maximize muscular and power gains. ‘Cutting stacks’ consist of combinations containing potent androgens, that are most popular for
  dieting and physique definition, because of their lack
  of estrogenic exercise (less water, salt and fat retention).
  Heavy users may combine a ‘mass-building cycle’, then ‘cutting cycle’, to
  complete by a ‘post-cycle therapy’ together with anti-estrogens or human Chorionic Gonadotropin (hCG), to try to restart androgen manufacturing by the testicles.

  It’s essential to note that the proof linking
  paternal anabolic steroid use to birth defects is presently limited and largely theoretical.
  Extra analysis is required to understand the potential dangers and mechanisms involved.
  This analysis wouldn’t only help to clarify the risks but in addition guide healthcare
  professionals in advising sufferers who have used or are considering utilizing anabolic steroids
  and want to begin a family.
  The use of selective estrogen receptor modulators (SERMs) or human chorionic gonadotropin (HCG) and steroids in scientific research has proven that this will forestall the
  negative effects of anabolic steroids on sperm quality. Using Anavar and
  other anabolic steroids carries potential dangers to male reproductive health, together with diminished sperm high
  quality and hormonal imbalances. In wrapping
  up our dialogue about Anavar and its position in feminine fertility, it’s crucial to
  consider the multifaceted impact this anabolic steroid can have on women’s well being.

  Whereas Anavar might sound interesting for its potential to boost
  athletic efficiency and promote lean muscle gain, these
  benefits include vital dangers, particularly regarding reproductive health.

  The effects of Anavar on female fertility are usually
  reversible after the drug is stopped. In this complete article,
  we delve deep into the subject to provide insights, professional opinions, and answers to regularly requested questions.
  Let’s navigate the world of Anavar and its potential affect on female fertility.
  Steroid use could cause numerous menstrual irregularities, corresponding
  to amenorrhea (absence of menstruation), oligomenorrhea (infrequent menstruation), and menorrhagia (heavy menstrual bleeding).

  These irregularities are sometimes indicative of underlying hormonal disturbances that can impede fertility.

  Steroids, generally known for his or her
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• Anadrol training routine:

  01/11/2025 в 08:52

  Do not share oxandrolone with different folks, even when they have the identical condition as you.

  In common, people who have breast most cancers should also not
  take this medication. Oxandrolone should be stored at room
  temperature, between 68 F and seventy seven F
  (20 C and 25 C). It may be uncovered to temperatures between fifty nine F and 86 F (15 C and 30 C) for shorter durations
  of time, similar to when transporting it. However, its mild nature and excessive tolerance amongst men and women make it a preferred steroid from a security perspective.
  Studies recommend Anavar’s ability to burn VF is due to its optimistic impact
  on insulin sensitivity and rising T3 levels (triiodothyronine), a hormone crucial in the regulation of adipose tissue and
  metabolism.
  To attempt to fight this, British Dispensary locations a logo holograph
  on the bottles, which you should take special care to verify upon purchase.
  If you’ve used Testosterone enanthate or cypionate, wait two weeks earlier
  than beginning PCT. It’s necessary to repeat
  that this is a highly advanced strategy that goes beyond what most ladies will be trying to use Winstrol for – particularly if
  you’re somebody who needs to avoid virilization at all costs.
  One of the more unique potential medical makes use of researched for Winstrol pertains to dermatological (skin) situations like Raynaud’s phenomenon and different situations where some success has been seen in studies[1].
  All of our steroids are made with the best normal of quality and ethics.
  We have all kinds of anablolic steroids available within the USA from
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  Really only Dianabol, Winstrol, Anadrol, and Anavar within the
  realm of worthwhile oral mass builders – with a few fringe niche exceptions like Superdrol and Methyl-1-Testosterone.

  At this time, the Federal Meals, Drug, and Beauty Act, was invoked
  to limit the access of steroids, making them available solely by prescription. Anavar isn’t broadly known as a
  strength-enhancing steroid, but it excels on this regard, and one purpose is
  that the ATP uptake in muscle cells is elevated.
  You’re likely to see a great enchancment in the amount of weight you presumably can raise when utilizing Anavar.
  Positive reviewers will state that Anavar is probably the most
  well-tolerated steroid they’ve used.
  A two-week break follows the cycle adopted up with three weeks
  of PCT (100mg/day Clomid for ten days, then followed up with 50mg/day Clomid
  for an additional ten days). This stack will permit speedy features at the start with Anadrol, whereas testosterone and
  Deca kick in as slower-acting injectables for the remainder of the
  cycle. At the very least, Anadrol will at all times be run with a
  testosterone base in a stack (for men only). This could be a TRT dose of testosterone to maintain estrogen levels and regular perform.

  Or you possibly can enhance the testosterone dose to contribute
  more anabolic effects. Nonetheless, if used on the front finish of
  your bulking cycles, 100mg of Anadrol training routine every day for 4-6 weeks is likely the place essentially the most advanced customers will begin,
  combined with 1mg of Arimidex every day to fight unwanted effects.

  Many people will swear by solely using Anadrol with a testosterone base, but using it
  alone can also be a viable choice.
  Therefore, bodybuilders generally complement with TUDCA during or after a cycle
  for liver safety. In one research, 53 patients took 500 mg of
  TUDCA per day for 3 months (10). It was effective in decreasing AST and ALT enzymes inside the first month.
  This effect was vital by the third month, with AST and ALT enzymes dropping
  by 44% and 49%, respectively. A 20-year-old Japanese lady who suffered from aplastic anemia was treated with Anadrol, taking 30 mg/day
  for six years (this is a very long time). Despite growing
  a number of liver lesions, a lab evaluation found her liver perform to be regular (8).
  This is a lucky outcome contemplating she was taking this excessive dose (for a female) for six years.

  Although females can and do use Winstrol on their very own in a cycle, it will be virtually unprecedented (and not recommended) for men to do the same.
  At the very least, male Winstrol customers do must stack Winstrol with a
  type of testosterone at the minimal dosage to act as a testosterone alternative through
  the cycle to combat Winstrol’s suppressive effects.
  Due to Winstrol’s substantial liver toxicity (including the
  injectable version), we need to be careful when stacking it with some other C17-alpha alkylated AAS
  and limit the cycle to just some weeks. I mention this specifically because
  one of many stack ideas I often come upon is a Winstrol/Anavar stack.

  This is an ultimate stack that can literally rework your body
  and do it quick. Sure, you have to work onerous along with your food plan and coaching right here; otherwise, don’t bother with this
  cycle. Trenbolone comes with some hardcore unwanted side effects that you’ll wish to be acquainted with and
  prepared to manage, particularly in phrases of the psychological unwanted side effects that may
  negatively impression your well being. This stack may also be exhausting in your liver,
  so have your helps prepared. Winstrol use among females has become more frequent,
  and it will almost solely be oral Winstrol. This is a low dose, but
  every additional milligram a female takes of Winny does make a big
  distinction and runs the danger of taking you from a tolerable cycle to 1 the place virilization begins
  to creep in. Men who use Winstrol will primarily be preparing
  for a contest and using Winny on the ultimate levels of a cycle that has included any number of
  AAS.
  What I’ve discovered after years of analysis
  is that every single person who uses Anadrol has a different
  expertise. That makes it exhausting to know what to expect, particularly if it’s your first time.
  To maximize fats loss and weight reduction, customers ought to eat in a calorie deficit (-500 calories per day), which
  may also maximize muscle retention. We have discovered that calorie
  deficits higher than this (starvation diets) can result in water storage and muscle loss.